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Liquid chromatography-mass spectrometry (LC-MS) is a technique borrowed from analytical chemistry that amalgamates the proficiency of both the Liquid Chromatography (LC) and Mass Spectrometry (MS). It combines the physical separation capabilities of LC with the mass analysis capabilities of MS. These tests are the laboratory techniques for identification, quantization and mass analysis of materials. Currently, liquid chromatography-mass spectrometers (LC-MS) are increasingly being used in a wide range of fields, such as pharmaceuticals, environment, foods, and industrial materials.
Congenital adrenal hyperplasia (CAH) refers to a group of autosomal recessive disorders that impair cortisol biosynthesis. CAH represents a continuous phenotypic spectrum with over 95% of all cases caused by 21-hydroxylase deficiency. CAH owing to 21-hydroxylase deficiency is the most common cause of genital ambiguity in the newborn and is present in about 1 in 15,000 live births worldwide
Expanded newborn screening panel for quantitative determination of 15 Amino acids, free Carnitines, 12 Acylcarnitines, Argininosuccinic acid (ASA) and Succinylacetone (SUAC) under the same extraction method and single injection/single run step without using any toxic compounds, on Tandem MS